Mitochondrial-Derived Peptide · Metabolic Regulator · 10mg/vial · Research Grade
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Compound Overview
Classification
MOTS-c (Mitochondrial Open reading frame of the twelve S rRNA-c) is a 21-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of mitochondrial DNA. Unlike nuclear-encoded peptides, MOTS-c originates from the mitochondrial genome and functions as a mitochondrial signal regulating systemic metabolism, exercise response, and cellular stress adaptation.
Mechanisms of Action
Activates AMP-activated protein kinase — a master regulator of cellular energy homeostasis — improving glucose uptake and fatty acid oxidation.
Inhibits MTHFD2 in the folate cycle, reducing purine synthesis and redirecting metabolic flux toward adaptive stress responses.
Translocates from mitochondria to the nucleus under metabolic stress; directly modulates gene expression of antioxidant and metabolic pathways.
Replicates key metabolic benefits of physical exercise in research models, including improved muscle glucose utilization and mitochondrial biogenesis.
Research Findings
Metabolic
Improves insulin sensitivity and glucose homeostasis in obesity and type 2 diabetes research models
Longevity
Declines with age in humans; restoration associated with improved healthspan markers in aging research
Exercise
Mimics key metabolic adaptations of physical exercise including AMPK activation and mitochondrial biogenesis
Research Areas
Metabolic syndrome and insulin resistance
Aging and longevity biology
Exercise physiology and muscle metabolism
Obesity and adipose tissue research
Mitochondrial dysfunction models
Cellular stress response and adaptation
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FDA Disclosure
The statements made regarding our products have not been evaluated by the Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. All information is for educational purposes only and is not a substitute for medical advice. Do not use if pregnant, nursing, or under 21.
MgBotanic is not liable for any adverse effects or misuse of its products.
Product Description
Product is NOT FOR HUMAN CONSUMPTION. Sold strictly for Research, Novelty, and Collection Purposes only. Not intended for human or animal consumption.
Age Restriction — 21+
This product is intended for adults 21 years and older. By purchasing, you confirm you are at least 21 years of age.
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By purchasing this product, you agree that the seller is not responsible for any adverse effects or consequences resulting from the use or misuse of this product. All products are sold for legal use only.